Staining of normal human peripheral blood cells with APC Anti-Human CD19 Antibody and AF488 Anti-Human CD95/Fas Antibody[HFE7A/APO] (left) or AF488 Mouse IgG2a, κ Isotype Control (right). Cells in the lymphocytes gate were used for analysis.
CD95 is a 45 kD single chain type I glycoprotein also known as Fas, APO-1, and TNFRSF6. It is a member of the TNF receptor superfamily. CD95 is expressed on T and B lymphocytes, monocytes, neutrophils, and fibroblasts. CD95 expression is upregulated by activation. The extracellular region of CD95 binds to CD178 (Fas ligand). CD178 binding to CD95 induces apoptosis and has been shown to play a role in the maintenance of peripheral tolerance.
![Staining of normal human peripheral blood cells with APC Anti-Human CD19 Antibody and AF488 Anti-Human CD95/Fas Antibody[HFE7A/APO] (left) or AF488 Mouse IgG2a, κ Isotype Control (right). Cells in the lymphocytes gate were used for analysis.](/upload/ec/antibodies/RD30851F-FC01.jpg)
