Rat splenocytes are stained with AF 488 Anti-Rat CD45RA Antibody (filled gray histogram) or AF 488 Mouse IgG1, κ Isotype Control (empty black histogram).
CD45 is a protein tyrosine phosphatase with multiple isoforms differing as a result of alternative splicing of the extracellular domain and glycosylation. CD45 is expressed on all hematopoietic cells except erythrocytes and platelets. CD45RA is one of the CD45 isoforms with a molecular weight of 200-220 kD. It is expressed almost exclusively on B cells. CD45 functions in signal transduction through T and B cell antigen receptors. CD45 has been shown to interact with various proteins, including galectin-1, CD2, CD3, and CD4.
Immunogen Information
Gene ID
24699
Synonyms
Leukocyte common antigenhigh molecular weight form
