C57BL/6 murine splenocytes are stained with FITC Anti-Mouse NK1.1 Antibody and AF 647 Anti-Mouse CD335 Antibody (Left). Splenocytes are stained with FITC Anti-Mouse NK1.1 Antibody and AF 647 Rat IgG2a, κ Isotype Control (Right).
CD335, also known as NKp46, is a single-pass type I membrane protein of 46 kD. It belongs to the natural cytotoxicity receptor (NCR) family and contains two Ig-like (immunoglobulin-like) domains. It's expression is restricted to NK cells and a subset of NKT cells; it's not expressed in CD1d-restricted NKT cells. CD335 is a receptor for viral hemagglutinins and heparan sulfate proteoglycans and is involved in NK cell activation.
