C57BL/6 murine splenocytes are stained with APC Anti-Mouse CD45R/B220 Antibody and AF Violet 450 Anti-Mouse CD5 Antibody (Left). Splenocytes are stained with APC Anti-Mouse CD45R/B220 Antibody and AF Violet 450 Rat IgG2a, κ Isotype Control (Right).
CD5 is a 67 kD protein, also known as Lyt-1, Ly-1, T1, Tp67, or Ly-12. It is a member of the scavenger receptor cysteine-rich protein superfamily (SRCR) and primarily expressed on thymocytes, T cells, and B-1 cells. Although mature α/β T cells express high levels of CD5, very few γ/δ T cells express this antigen. The interaction of CD5 with CD72, gp35-37, TCR, or BCR is involved in T and B cell activation.
