Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BIM(Phospho-Ser69) Antibody (RDSA62267)(left) or the same antibody preincubated with blocking peptide(right).
Immunofluorescence staining of methanol-fixed Hela cells using BIM(Phospho-Ser69) Antibody (RDSA62267).
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.
Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-a1, isoform Bim-a2 and isoform Bim-a3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
Immunogen Information
Immunogen
Peptide sequence around phosphorylation site of serine 69 (P-A-S(p)-P-G) derived from Human BIM.
Gene ID
10018
Swissprot
O43521
Synonyms
BCL2-like protein 11;BCL2L11;BOD;Bcl-2 related ovarian death protein
