C57BL/6 murine bone marrow cells are stained with FITC Anti-Mouse CD45R/B220 Antibody and Biotin Anti-Mouse CD31 Antibody followed by Streptavidin-AF 647 (Left). Bone marrow cells are stained with FITC Anti-Mouse CD45R/B220 Antibody and Biotin Rat IgG2a, κ Isotype Control followed by Streptavidin-AF 647 (Right).
CD31 is a 130-140 kD glycoprotein, also known as platelet endothelial cell adhesion molecule (PECAM-1) and EndoCAM. It is a member of the Ig superfamily, expressed on endothelial cells, platelets, granulocytes, monocytes/macrophages, dendritic cells, and T and B cell subsets, and is critical for cell-cell interactions. The primary ligands for CD31 have been reported to be CD38 and the vitronectin receptor (αv β3 integrin, CD51/CD61). Other reported functions of CD31 are neutrophil emigration to sites of inflammation and angiogenesis.
