ERBB2 Monoclonal Antibody

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Catalog NumberRD85466A

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Overview
Product NameERBB2 Monoclonal Antibody
Catalog NumberRD85466A
Purification MethodProtein A purification
IsotypeIgG
HostMouse
Clone NumberClone:1J5
Background

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

Immunogen Information
ImmunogenSynthetic Peptide
SwissprotP04626
SynonymsC erb B2/neu proteinCD340CD340 antigenCerb B2/neu proteinCerbB2Erb b2 receptor tyrosine kinase 2ERBB2HER 2HER 2/NEUHER2HerstatinHuman epidermal growth factor receptor 2Metastatic lymph node gene 19 proteinMLN 19MLN19NEUNEU proto oncogeneNeuro/glioblastoma derived oncogene homologNeuroblastoma/glioblastoma derived oncogene homologNGLp185erbB2Proto-oncogene c-ErbB-2Proto-oncogene NeuReceptor tyrosine-protein kinase erbB-2TKR1Tyrosine kinase type cell surface receptor HER2Tyrosine kinase-type cell surface receptor HER2V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)V erb b2 avian erythroblastic leukemia viral oncogene homolog 2V erb b2 avian erythroblastic leukemia viral oncoprotein 2V erb b2 erythroblastic leukemia viral oncogene homolog 2neuro/glioblastoma derived oncogene homologVerb b2 erythroblastic leukemia viral oncogene homolog 2neuro/glioblastoma derived oncogene homolog (avian)
Applications
ReactivityHuman,Mouse,Rat
Tested applicationsWB,IHC-p,IF
ConjugationUnconjugated
DilutionWB 1:500-1:4000, IHC 1:100-1:300, IF 1:100-1:300
Dilution1 mg/mL
Storage BufferPBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Storage InstructionsStore at -20°C. Avoid freeze / thaw cycles.
Research Area

Cancer, Immunology, Signal Transduction, Tags and Cell Markers

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