Western Blot with Recombinant Phospho-IGF1R (Tyr1135/1136)/Phospho-Insulin Receptor β (Tyr1150/1151) Monoclonal Antibody at dilution of 1:1000 dilution. Lane A: NIH-3T3 whole cell lysate.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Immunogen Information
Immunogen
A synthetic peptide corresponding to residues around (Tyr1135/1136)/(Tyr1150/1151) of Human Phospho-IGF1R/Phospho-Insulin Receptor β
