Recombinant Prealbumin/Transthyretin Monoclonal Antibody

Transthyretin (TTR) is a highly conserved homotetremric protein that is synthesized in the liver and choroid plexus of the brain. TTR wasoriginally discovered as a protein found in human plasma and cerebrospinal fluid (CSF). TTR transports thyroid hormones (TH) and retinol bybinding to retinol-binding protein. Although TTR is synthesized in the liver and choroid plexus, TTR is detected in blood plasma andcerebrospinal fluid migrating as monomers, dimers, and tetramers. Beyond its function as a carrier protein of TH and retinol in plasma andCSF, several additional TTR functions have been described, including proteolytic cleavage of specific substrates like apolipoprotein, neuropeptide Y (NPY), and APP. These neuronal substrates suggest a functional role for TTR in the central nervous system. Consistent witha CNS function, TTR null mice exhibit memory impairments and altered sensorimotor behavior). TTR may also be linked to neurodegenerativedisease: TTR levels in Alzheimer’s disease (AD) patients are negatively correlated with disease progression, and a protective role for TTR, atleast in AD mouse models, has been described. TTR itself may play a more direct role in disease as gain-of-function mutations in TTR causethe protein to misfold and aggregate into amyloid fibrils, contributing to autosomal dominant hereditary amyloidosis in diseases such as familialamyloid polyneuropathy, familial amyloid cardiomyopathy, and familial leptomeningeal amyloidosis.