Western Blot with UQCRFS1/RISP Monoclonal Antibody at dilution of 1:5000. Lane 1: Raji, Lane 2: HeLa, Lane 3: U87-MG, Lane 4: Human heart, Lane 5: mouse heart, Lane 6: Rat heart
Immunohistochemistry of paraffin-embedded Human kidney using UQCRFS1/RISP Monoclonal Antibody at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded Human cervical cancer using UQCRFS1/RISP Monoclonal Antibody at dilution of 1:1000.
Immunoprecipitation analysis using anti-UQCRFS1/RISP Monoclonal Antibody. Western blot was performed from the immunoprecipitate using UQCRFS1/RISP Monoclonal Antibody at a dilution of 1:100. Lane 1: 5% Input, Lane 2: UQCRFS1/RISP Monoclonal Antibody, Lane 3: Rabbit monoclonal IgG Isotype
Ubiquinol-cytochrome c reductase iron-sulfur subunit (UQCRFS1), also known as Rieske iron-sulfur protein (RISP), is a component of Complex III in the mitochondrial electron transport chain. UQCRFS1/RISP and two other subunits, cytochrome b (MT-CYB) and cytochrome c1 (CYC1), are essential for the catalytic activity of Complex III. Studies show that UQCRFS1/RISP is required for fetal mouse hematopoietic stem cell differentiation and adult mouse hematopoietic stem cell quiescence. In addition, loss of UQCRFS1/RISP decreases the strength of T cell receptor (TCR) signaling, indicating that this protein is critical for optimal TCR signaling.
