Western Blot with Vitamin D Receptor Monoclonal Antibody at dilution of 1:3000. Lane 1: T-47D, Lane 2: NIH-3T3
Western Blot with Vitamin D Receptor Monoclonal Antibody at dilution of 1:3000. Lane 1: HL-60
Immunoprecipitation analysis using anti-Vitamin D Receptor Monoclonal Antibody. Western blot was performed from the immunoprecipitate using Vitamin D Receptor Monoclonal Antibody at a dilution of 1:100. Lane 1: 10% Input, Lane 2: Vitamin D Receptor Monoclonal Antibody, Lane 3: Rabbit monoclonal IgG Isotype
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
Immunogen Information
Immunogen
Peptide. This information is proprietary to PTMab.
Swissprot
P11473
Synonyms
NR1Inuclear receptor subfamilyPPP1RmemberVDRNR1I1PPP1R163group Imember 1nuclear receptor subfamily 1vitamin D receptor
