HMGB1 Polyclonal Antibody

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Catalog NumberRD70218A

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Overview
Product NameHMGB1 Polyclonal Antibody
Catalog NumberRD70218A
Purification MethodAffinity purification
IsotypeIgG
HostRabbit
Background

High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.

Immunogen Information
ImmunogenRecombinant Human High mobility group protein B1 protein
SwissprotP09429
SynonymsAmphoterinChromosomal proteinnonhistoneDKFZp686A04236High mobility group 1High mobility group box 1High mobility group protein 1High mobility group protein B1high-mobility group (nonhistone chromosomal) protein 1HMG-1HMG1HMG3HMGB 1HMGB1NONHISTONE CHROMOSOMAL PROTEIN HMG1SBP 1Sulfoglucuronyl carbohydrate binding protein
Applications
ReactivityHuman
Tested applicationsIHC
ConjugationUnconjugated
DilutionIHC 1:100-1:200
Dilution2 mg/mL
Storage BufferPBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Storage InstructionsStore at -20°C. Avoid freeze / thaw cycles.
Research Area

Cancer, Epigenetics and Nuclear Signaling

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