Western blot analysis of Mouse liver tissue Hela cell Human testis tissue Jurkat and HEPG2 cell lysates using ATF6B Polyclonal Antibody at dilution of 1:300
Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using ATF6B Polyclonal Antibody at dilution of 1:30(×200)
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.