BECN1 Monoclonal Antibody
Catalog Number
RD85560A
Western Blot analysis of 1) 293T, 2) C2C12, 3) Rat brain using BECN1 Monoclonal Antibody at dilution of 1:2000.
Immunohistochemistry of paraffin-embedded Human brain tissue using BECN1 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using BECN1 Monoclonal Antibody at dilution of 1:200.
Variation
Quantity
For more information on our kits, please contact us at info@reddotbiotech.com
Overview
Product Name
BECN1 Monoclonal Antibody
Catalog Number
RD85560A
Clonality
Monoclonal
Purification Method
Protein A purification
Isotype
IgG
Host
Mouse
Background
Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
Immunogen Information
Immunogen
Synthetic Peptide of Beclin-1
Swissprot
Q14457
Synonyms
APG6ATG 6ATG6ATG6 autophagy related 6 homologBcl-2-interacting protein beclinBeclin 1 (coiled coil moesin like BCL2 interacting protein)Beclin 1 autophagy relatedBeclin-1Beclin1BECN 1Becn1BECN1Coiled coil myosin like BCL2 interacting proteinC
Observed MW
60 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p
Conjugation
Unconjugated
Dilution
WB 1:1000-2000, IHC 1:100-200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.