c-Fos Polyclonal Antibody
Catalog Number
RD70941A
Western Blot analysis of 3T3, Hela cells using c-Fos Polyclonal Antibody at dilution of 1:1000.
Variation
Quantity
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Overview
Product Name
c-Fos Polyclonal Antibody
Catalog Number
RD70941A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
Immunogen Information
Immunogen
Synthesized peptide derived from the N-terminal region of human c-Fos
Swissprot
P01100
Synonyms
Activator protein 1AP 1C FOSCellular oncogene c fosCellular oncogene fosFBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS)FBJ murine osteosarcoma viral oncogene homologFBJ murine osteosarcoma viral v fos oncogene homologFBJ Oste
Calculated MW
41 kDa
Observed MW
62 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas