This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
Immunogen Information
Immunogen
Synthetic Peptide of CHOP
Swissprot
P35638
Synonyms
C/EBP homologous proteinC/EBP Homology ProteinC/EBP zetaC/EBP-homologous protein 10C/EBP-homologous proteinCCAAT/enhancer binding protein homologous proteinCEBPZCHOP 10CHOPCHOP-10CHOP10DDIT 3DDIT-3Ddit3DDIT3DNA Damage Inducible Transcript 3
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC-p
Conjugation
Unconjugated
Dilution
IHC 1:100-200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4