This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.
Immunogen Information
Immunogen
Fusion protein of human ELOC
Swissprot
Q15369
Synonyms
Elongin CTranscription Elongation Factor B (SIII)Polypeptide 1 (15kDaElongin C)RNA Polymerase II Transcription Factor SIII Subunit CTranscription Elongation Factor B Polypeptide 1Transcription Elongation Factor B Subunit 1Elongin 15 KDa SubunitS