HDAC2 Polyclonal Antibody
Catalog Number
RD71261A
Western Blot analysis of Jurkat, 3T3 cells using HDAC2 Polyclonal Antibody at dilution of 1:2000.
Variation
Quantity
For more information on our kits, please contact us at info@reddotbiotech.com
Overview
Product Name
HDAC2 Polyclonal Antibody
Catalog Number
RD71261A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity.
Immunogen Information
Immunogen
Synthesized peptide derived from human HDAC2 around the non-phosphorylation site of Ser394.
Swissprot
Q92769
Synonyms
D10Wsu179eHD 2HD2HDAC 2Hdac2HDAC2Histone deacetylase 2 (HD2)Histone deacetylase 2OTTHUMP00000017046OTTHUMP00000227077OTTHUMP00000227078RPD3transcriptional regulator homolog RPD3YAF1YY1 associated factor 1YY1 transcription factor binding pro
Calculated MW
55 kDa
Observed MW
55 kDa
Applications
Reactivity
Human,Mouse,Rat,Monkey
Tested Applications
WB,IHC-p,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.