HIPK3 Polyclonal Antibody
Catalog Number
RD219326A
Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using HIPK3 Polyclonal Antibody at dilution of 1:60(×200)
Variation
Quantity
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Overview
Product Name
HIPK3 Polyclonal Antibody
Catalog Number
RD219326A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Immunogen Information
Immunogen
Synthetic peptide of human HIPK3
Swissprot
Q9H422
Synonyms
Androgen receptor interacting nuclear protein kinaseAndrogen receptor-interacting nuclear protein kinaseANPKDYRK6Fas interacting serine/threonine protein kinaseFas-interacting serine/threonine-protein kinaseFISTFIST3Hipk3HIPK3homeodomain interac
Gene Accession
NP001041665
Applications
Reactivity
Human, Mouse, Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:300, ELISA 1:5000-1:10000
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.