Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
Immunogen Information
Immunogen
Recombinant Mouse Matrix metalloproteinase-9 protein
Gene ID
17395
Swissprot
P41245
Synonyms
82 kDa matrix metalloproteinase-992 kDa gelatinaseCLG4BCollagenase Type 4 betaEC 3.4.24.35Gelatinase 92 KDGelatinase betaGelatinaseBGELBMacrophage gelatinaseMANDP2MMP 9Type V collagenase