MSH4 Polyclonal Antibody
Catalog Number
RD266200A
Western blot analysis of extracts of SKOV3 cells using MSH4 Polyclonal Antibody at dilution of 1:1000.
Immunofluorescence analysis of Rat testis using MSH4 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Variation
Quantity
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Overview
Product Name
MSH4 Polyclonal Antibody
Catalog Number
RD266200A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.
Immunogen Information
Immunogen
Recombinant fusion protein of human MSH4 (NP_002431.2).
Gene ID
4438
Swissprot
O15457
Synonyms
MSH4
Calculated MW
104 kDa
Observed MW
105 kDa
Applications
Reactivity
Human,Rat
Tested Applications
WB,IF
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000 IF 1:50-1:200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas