P38 Polyclonal Antibody
Catalog Number
RD71595A
Western Blot analysis of Hela cells using p38 Polyclonal Antibody at dilution of 1:1000.
Variation
Quantity
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Overview
Product Name
P38 Polyclonal Antibody
Catalog Number
RD71595A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.
Immunogen Information
Immunogen
Synthesized peptide derived from human p38 around the non-phosphorylation site of Tyr323.
Swissprot
Q16539
Synonyms
CSAID Binding Protein 1CSAID binding proteinCSAID-binding proteinCsaids binding proteinCSBP 1CSBP 2CSBPCSBP1CSBP2CSPB1Cytokine suppressive anti-inflammatory drug-binding proteinEXIPMAP kinase 14MAP kinase MXI2MAP kinase p38 alphaMAPK 14MAP
Calculated MW
41 kDa
Observed MW
38 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p,IF,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas