PMA and ionomycin-stimulated (4h) Jurkat cells are stained with Anti-Human CD83 Monoclonal Antibody(PE Conjugated)(filled gray histogram) or Mouse IgG1, κ Isotype Control(PE Conjugated)(empty black histogram).
CD83 is a 43 kD single chain type I glycoprotein also known as HB15. A member of the immunoglobulin superfamily, CD83 is expressed on a subset of dendritic cells, Langerhans cells, and weakly on activated lymphocytes. Although CD83 is thought to play a role in antigen presentation and/or lymphocyte activation, the precise function of this protein is unknown. CD83 is considered to be a useful marker for mature dendritic cells.