PERK Polyclonal Antibody
Catalog Number
RD232546A
Western Blot analysis of Hela cells using PERK Polyclonal Antibody at dilution of 1:2000.
Variation
Quantity
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Overview
Product Name
PERK Polyclonal Antibody
Catalog Number
RD232546A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.
Immunogen Information
Immunogen
Synthesized peptide derived from the N-terminal region of human PERK
Swissprot
Q9NZJ5
Synonyms
DKFZp781H1925E2AK3EC 2.7.11.1Eif2ak3Eukaryotic translation initiation factor 2 alpha kinase 3Eukaryotic translation initiation factor 2-alpha kinase 3Heme regulated EIF2 alpha kinaseHRIHsPEKPancreatic eIF2 alpha kinasePancreatic eIF2-alpha kinas
Calculated MW
125 kDa
Observed MW
125 kDa
Applications
Reactivity
Human
Tested Applications
WB,IHC-p,IF,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas