Phospho-Rb(S811) Polyclonal Antibody
Catalog Number
RD268083A
Western blot analysis of extracts of HeLa cells using Phospho-Rb(S811) Polyclonal Antibody at dilution of 1:1000. HeLa cells were treated by UV for 15-30 minutes.
Immunofluorescence analysis of U2OS cells using Phospho-Rb(S811) Polyclonal Antibody
Variation
Quantity
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Overview
Product Name
Phospho-Rb(S811) Polyclonal Antibody
Catalog Number
RD268083A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Immunogen Information
Immunogen
A synthetic phosphorylated peptide around S811 of human Rb (NP_000312.2).
Gene ID
5925
Swissprot
P06400
Synonyms
OSRCPPP1R130RBp105-RbpRbpp110RB1Rb
Calculated MW
106 kDa
Observed MW
106 kDa
Applications
Reactivity
Human
Tested Applications
WB,IF
Conjugation
Unconjugated
Dilution
WB 1:1000-1:2000 IF 1:50-1:100
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas