Phospho-RB1(S780) Polyclonal Antibody
Catalog Number
RD268146A
Western blot analysis of extracts of NIH/3T3 cells using Phospho-RB1(S780) Polyclonal Antibody.
Variation
Quantity
For more information on our kits, please contact us at info@reddotbiotech.com
Overview
Product Name
Phospho-RB1(S780) Polyclonal Antibody
Catalog Number
RD268146A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Immunogen Information
Immunogen
A phospho specific peptide corresponding to residues surrounding S780 of human RB1
Gene ID
5925
Swissprot
P06400
Synonyms
OSRCPPP1R130RBp105-RbpRbpp110RB1Rb
Calculated MW
106 kDa
Observed MW
100 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas