Western blot analysis of extracts of 293T cells using Phospho-β-catenin(S33/S37/T41) Polyclonal Antibody.
Immunohistochemistry of paraffin-embedded Human skin using Phospho-β-catenin(S33/S37/T41) Polyclonal Antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Human colon carcinoma using Phospho-β-catenin(S33/S37/T41) Polyclonal Antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Human lung cancer using Phospho-β-catenin(S33/S37/T41) Polyclonal Antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Rat skin using Phospho-β-catenin(S33/S37/T41) Polyclonal Antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Mouse kidney using Phospho-β-catenin(S33/S37/T41) Polyclonal Antibody at dilution of 1:100 (40x lens).
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Immunogen Information
Immunogen
A synthetic phosphorylated peptide around S33 & T41 of human beta Catenin (NP_001091679).