Rb Polyclonal Antibody
Catalog Number
RD265819A
Immunofluorescence analysis of Y79 cells using Rb Polyclonal Antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Variation
Quantity
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Overview
Product Name
Rb Polyclonal Antibody
Catalog Number
RD265819A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Immunogen Information
Immunogen
Recombinant fusion protein of human Rb (NP_000312.2).
Gene ID
5925
Swissprot
P06400
Synonyms
OSRCPPP1R130RBp105-RbpRbpp110RB1Rb
Applications
Reactivity
Human,Mouse
Tested Applications
IF
Conjugation
Unconjugated
Dilution
IF 1:100-1:200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas