This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Fusion protein of human RBFOX2
Swissprot
O43251
Synonyms
HRNBP2Fox 1 homologueFox-1 homolog BFOX2FXHHexaribonucleotide-binding protein 2HNRBP2RBFOX2Repressor of tamoxifen transcriptional activityRFOX2RNA binding motif protein 9RNA binding protein 9RNA binding protein fox-1 homolog 2RNA-binding moti