The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.
Immunogen Information
Immunogen
Synthesized peptide derived from the N-terminal region of human S-100 α
Swissprot
P23297
Synonyms
BpbNEFProtein S100-A1S-100 protein alpha chainS-100 protein subunit alphaS100 alphaS100 betaS100 calcium binding protein A1S100 calcium binding protein BS100 calcium-binding protein A1S100 protein alpha polypeptideS100As100a1S100BS100betaS1
Calculated MW
11 kDa
Observed MW
10 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p,IF,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4