SMAD2 Polyclonal Antibody
Catalog Number
RD71786A
Western Blot analysis of COLO205 cells with Smad2 Polyclonal Antibody.
Variation
Quantity
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Overview
Product Name
SMAD2 Polyclonal Antibody
Catalog Number
RD71786A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma.
Immunogen Information
Immunogen
Synthesized peptide derived from human Smad2 around the non-phosphorylation site of Ser250.
Swissprot
Q15796
Synonyms
Drosophilahomolog ofMADR2hMAD-2HsMAD2JV18JV18-1JV181MADMAD homolog 2MAD Related Protein 2Mad-related protein 2MADH2MADR2MGC22139MGC34440Mother against DPP homolog 2Mothers against decapentaplegic homolog 2Mothers against decapentaplegic
Calculated MW
52 kDa
Observed MW
52 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.