SNCA Polyclonal Antibody
Catalog Number
RD236111A
Variation
Quantity
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Overview
Product Name
SNCA Polyclonal Antibody
Catalog Number
RD236111A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
Immunogen Information
Immunogen
Synthesized peptide derived from the Internal region of human Synuclein-α.
Swissprot
P37840
Synonyms
Alpha synucleinAlpha-synucleinAlpha-synucleinisoform NACP140alphaSYNMGC105443MGC110988MGC127560MGC64356NACPNon A beta component of AD amyloidNon A4 component of amyloidNon A4 component of amyloid precursorNon-A beta component of AD amyloidNo
Calculated MW
14 kDa
Observed MW
15 kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC-p,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300 ELISA 1:10000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas