TPMT Polyclonal Antibody
Catalog Number
RD218800A
Western blot analysis of Human kidney tissue lysate using TPMT Polyclonal Antibody at dilution of 1:400
Variation
Quantity
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Overview
Product Name
TPMT Polyclonal Antibody
Catalog Number
RD218800A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
Immunogen Information
Immunogen
Fusion protein of human TPMT
Swissprot
P51580
Synonyms
HGNC:12014S adenosyl L methionine thiopurine S methyltransferaseThiopurine methyltransferaseThiopurine S methyltransferaseThiopurine S-methyltransferaseTPMTTPMT
Calculated MW
28 kDa
Observed MW
Refer to figures
Gene Accession
BC005339
Applications
Reactivity
Human
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, ELISA 1:5000-1:10000
Concentration
0.96 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas