YY1 Polyclonal Antibody

YY1,also named as DELTA,INO80S and NF-E1,contains four C2H2-type zinc fingers and belongs to the YY transcription factor family. YY1 is a multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter,thus implicating histone modification in the YY1. The open reading frame of the human YY1 cDNA encodes a protein of 414 amino acids with a predicted molecular weight of 44 kDa. However,YY1 migrates on SDS gels as a 65–68 kDa protein,probably due to the structure of the protein. It is a ubiquitously expressed transcription factor with fundamental roles in embryogenesis,differentiation,replication and proliferation.