Citation Spotlight: Rat FSH and LH

A recent study looking at the effects of Mentha longifolia as an herbal contraceptive used Reddot Biotech’s Rat follicle stimulating hormone and luteinizing hormone ELISA kits as part of the research. In this post, we’ll take a closer look at the study and the outcomes.

Mentha longifolia L: A Possible Herbal Contraceptive for Men

Mentha longifolia L (ML) is a plant that can be used as an herbal contraceptive. This study aimed to assess the toxicity profile and validate the antifertility effects of its leaves in male rats. The study found that ML usage is associated with oxidative stress and that excessive usage should be prohibited, however, the study also found that ML has possible contraceptive potential, but its usage should be carefully monitored.

Methods

The study used adult male Sprague Dawley rats that were divided into four groups. The Control group received .9% saline, while groups II, III, and IV received 50, 75, and 100 mg/kg/day ML doses for 28 days. The researchers analyzed the hormonal profile, sperm motility, and tissue histology of the rats. They also conducted a reversibility study to determine the effects of ML on pregnancy outcomes and litter size.

Findings

The study found that higher doses of ML resulted in decreases in spermatogonial populations, mature spermatids, seminiferous tubule diameter, lumen diameter, and epithelial height. The reversibility study depicted a reduction in both pregnancy outcomes and litter size. Besides contraceptive effects, ML usage is associated with oxidative stress, and as a result, it is important to consume this herb appropriately and keep the risks associated with high dosage in mind.

Importance of the Results

The study provides evidence that ML has possible contraceptive potential in male rats and could lead to further research on the use of ML as a male contraceptive. However, the study also highlights the importance of monitoring the usage of ML due to its association with oxidative stress. The results of this study could be useful in developing new male contraceptives that are safe and effective, and provide an alternative to hormonal contraceptives.

Overall, the study provides valuable insights into the possible contraceptive potential of ML in male rats. However, further research is needed to determine the safety and efficacy of ML as a male contraceptive in humans. 

This study uses Reddot Biotech’s RD-FSH-Ra and RD-LH-Ra ELISA kits. 

Check out all the other citations that mention the use of RD-FSH-Ra and RD-LH-Ra here:

Comparative effects of Bisphenol S and Bisphenol A on the development of female reproductive system in rats; a neonatal exposure study

Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: A focus on the possible hormonal mode of action

A biochemical and histological approach to study antifertility effects of methanol leaf extract of Asplenium dalhousiae Hook. in adult male rats

Neonatal exposure to furan alters the development of reproductive systems in adult male Sprague Dawley rats

Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)

Chronic exposure of bisphenol S (BPS) affect hypothalamic-pituitary-testicular activities in adult male rats: possible in estrogenic mode of action

Or, check out the list of citations for all other Reddot products, including citations for Human FSH, and Human and Mouse LH:

Reddot Biotech Citations