COVID-19 Spotlight: Human C Reactive Protein

C Reactive Protein (also known as C-RP; PTX1; Pentraxin-Related; Pentraxin 1) is a protein involved in the activation, amplification, and regulation of the complement system.² CRP is often also involved in defense related functions including identifying foreign pathogens and removal of damaged host cells.² As a result, levels of CRP are often elevated at the onset of infection, or immediately after tissue injury.² High levels of CRP have also been found in patients infected with COVID-19.³

Recent studies have looked at a variety of different biomarkers in relation to COVID-19, and several laboratory abnormalities associated with poor prognosis with COVID-19.⁴ Among these, the concentration of CRP in patients has been shown to be an important marker for infection outcome.⁵ Patients who die from a COVID-19 infection have been seen to maintain a high level of CRP.⁵ As a result, CRP is a possible predictor of prognosis for COVID-19 infection and can be a test for quickly identifying patients who may need enhanced monitoring for respiratory distress or dysfunction to avoid the worsening of their condition.⁶

Reddot Biotech is pleased to offer a Human C Reactive Protein ELISA kit in both our traditional and Ready-To-Use formats. Our Human CRP kits have a nanogram range (detection range 0.156-10ng/mL; sensitivity 0.057ng/mL) and are suitable for use with a wide variety of different sample types. For more information and to see the product manual, visit our product pages for RDR-CRP-Hu and RD-CRP-Hu. For any other questions, please feel free to contact us.

References and further reading:

1. CRP C-reactive protein [Homo sapiens (human)] - Gene - NCBI. (n.d.). Retrieved September 18, 2020, from https://www.ncbi.nlm.nih.gov/g...
2. McFadyen, J. D., Zeller, J., Potempa, L. A., Pietersz, G. A., Eisenhardt, S. U., & Peter, K. (2020). C-Reactive Protein and Its Structural Isoforms: An Evolutionary Conserved Marker and Central Player in Inflammatory Diseases and Beyond. In Vertebrate and Invertebrate Respiratory Proteins, Lipoproteins and other Body Fluid Proteins (pp. 499-520). Springer, Cham.
3. Gao, M., Wang, Q., Wei, J., Zhu, Z., & Li, H. Severe Coronavirus disease 2019 pneumonia patients showed signs of aggravated renal impairment. Journal of Clinical Laboratory Analysis, e23535.
4. Lippi, G., & Plebani, M. (2020). Laboratory abnormalities in patients with COVID-2019 infection. Clinical Chemistry and Laboratory Medicine (CCLM), 58(7), 1131-1134.
5. Sahu, B. R., Kampa, R. K., Padhi, A., & Panda, A. K. (2020). C-reactive protein: a promising biomarker for poor prognosis in COVID-19 infection. Clinica Chimica Acta.
6. Erika, P., Domenica, Z., Paolo, I., Luca, R., Giulia, L., Alessandro, D., ... & Andrea, M. (2020). Lactate dehydrogenase and C-reactive protein as predictors of respiratory failure in CoVID-19 patients. Clinica Chimica Acta.