Food and Chemical Toxicology · Elsevier BV · 2018-11-01
Asad Ullah, Madeeha Pirzada, Sarwat Jahan, et al.
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Asad Ullah, Madeeha Pirzada, Sarwat Jahan, Hizb Ullah, Naheed Turi, Waheed Ullah, Mariyam Fatima Siddiqui, Muhammad Zakria, Kinza Zafar Lodhi, Muhammad Munir Khan
American Journal of Reproductive Immunology · Wiley · 2018-08-12
Manu Banadakoppa, Meena Balakrishnan, Chandra Yallampalli
ProblemAntiangiogenic molecule soluble fms‐like tyrosine kinase receptor 1 (sFLT1) released from trophoblast cells is associated with pregnancy‐specific hypertensive disorder pre‐eclampsia. Cause of elevated sFLT1 in pre‐eclampsia patients is not well understood. Despite evidence of excess systemic and placental complement activation in pre‐eclampsia patients, its role in pathophysiology is not clear. If the complement activation plays a role in upregulation and secretion of sFLT1 is not known.Method of studyHuman trophoblast cells were isolated from term placentas and allowed to syncytialize. Complement was activated in vitro at sublethal levels on syncytiotrophoblast cells. Effect of complement activation on expression and release of sFLT1 was assessed by comparing its levels in these cells with and without complement activation.ResultsSublethal level of complement activation on syncytialized human trophoblast cells induced upregulation of sFLT1 mRNA and protein. Complement also induced secretion of sFLT1 i
Chemosphere · Elsevier BV · 2018-04-01
Nida Ahsan, Hizb Ullah, Waheed Ullah, et al.
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Nida Ahsan, Hizb Ullah, Waheed Ullah, Sarwat Jahan
EXCLI Journal · 2018-01-01
